Oncology Drug Discovery is complex, your research model should be too.
“The history of cancer research has been a history of curing cancer in the mouse. We have cured cancer for decades, and it simply didn’t work in humans”
This trend has continued, until now.
- Test thousands of drugs and combinations of drugs in over 500,000 avatars of each patient model
- 85% of the time, patients require a minimum combination of 2 or 3 drugs to combat their cancer
- Discover novel combinations, develop a biomarker strategy, and enable to repurposing of existing drugs
01 How it works
How it works
High throughput screening in a disease-relevant in-vivo model.
Our project team works with you to define the requirements of your study through to project execution and final report. Studies using existing avatars can be completed in less than a month.
01 As patients are recruited, tumour tissue is acquired
02 Each patient’s entire exome is analysed to capture their tumour’s network
03 Up to 20 genetic alterations from a patient’s tumour network are engineered into a fruit fly avatar
04 Up to 2000 FDA/NICE approved drugs plus novel compounds and combinations are screened in half a million avatars
02 Potential Use Cases
Potential Use Cases
Vivan avatars offer a range of potential use cases:
AScreening novel molecules
for efficacy & toxicity.
DPatient Stratification &
EDevelop custom avatar models
Bangi E, Murgia C, Teague AG, Sansom OJ, Cagan RL. Functional exploration of colorectal cancer genomes Using Drosophila. Nat Commun. 2016;7:13615. Published 2016 Nov 29. doi:10.1038/ncomms13615
Bangi E, Ang C, Smibert P, et al. A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Sci Adv. 2019;5(5):eaav6528. Published 2019 May 22. doi:10.1126/sciadv.aav6528